Huntington's Disease
Beginning of paper
Background
is inherited as an autosomal dominant disease that gives
rise to progressive, elective (localized) neural cell death associated with
choleric movements (uncontrollable movements of the arms, legs, and face) and
dementia. It is one of the more common inherited brain disorders. About 25,0 ....
Middle of paper
.... DNA)
mutations might contribute to the neurodegeneration observed in Huntington's
disease. Part of the research was to analyze cerebral deletion levels in the
temporal and frontal lobes. Research hypothesis: HD patients have significantly
higher mtDNA deletionlevels than agematched controls in the frontal and temporal
lobes of the cortex. To test the hypothesis, the amount of mtDNA deletion in 22
HD patients brains was examined by serial dilution-polymerase chain reaction
(PCR) and ....
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